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To minimize the effects of systemic adaptations to hypoxia, we used the two-stage chemical skin carcinogenesis model in which the topical application of the tumor initiating mutagen DMBA is followed by longer term treatment with phorbol esters (TPA).
Changes in haemoglobin mass reflect major systemic adaptations.
Therefore, the study of familial HCM may offer insight into metabolic and systemic adaptations stemming directly from the diseased cardiac myocyte.
Changes in conduit artery characteristics may be induced by the local effects of denervation (and consequent extreme inactivity below the level of the lesion), and also by systemic adaptations due to whole body inactivity.
19 Therefore, knowledge of both hepatic and adipocyte responses to a pro-inflammatory condition, such as SCE, might be important in understanding the cow's systemic adaptations to the disease.
Finally, some studies have reported enhanced upper limb resistance artery vasodilator capacity following predominantly lower limb exercise training interventions (Maiorana et al. 2001b; Silber et al. 1991), although the generalisability of this vascular adaptation remains somewhat controversial (Green et al. 2008a; Thijssen and Hopman 2008) (" Local versus systemic adaptations to exercise").
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Thus, this change in HCO3- concentration is mediated by chemical equilibrium, and not by any systemic adaptation.
To confirm that the lack of ketonemia in the "Carb-free" fed animals was not due to systemic adaptation following chronic exposure, we conducted a short-term experiment (e.g., 4 days) using the same treatment protocol.
From a physiological standpoint, reduced milking frequency represented a cue to signal lower mammary metabolic rate, hence, triggering systemic homeorhetic adaptations favoring use of nutrients (eg, glucose) for anabolic processes in other tissues.
We therefore set out to establish if greater improvements in systemic cardiovascular adaptation would be associated with changes in muscle gene expression.
Stimulating factors related to climate change are perceived of highest relevance for systemic and transformational adaptation whereas already implemented adaptation is mostly perceived to be incremental.
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