Thus, it is important to systematically verify that the amount of specific binding measured for a new MI agent indeed fluctuates concomitantly to changes in the expression of the targeted protein.
Before each single-molecule force spectroscopy (SMFS) experiment, it was systematically verified that ConA tips did not bind specifically to the PEI-coated glass where bacteria were immobilized prior to experiment (see Fig. S5).
We also systematically verify that these components exhibit minimal crosstalk and robust levels of fold change similar to their bacterial predecessors.
However, when developing new MI agents, it is essential to systematically verify several criteria: that the selectivity and affinity of the MI agent at the targeted protein remains optimal, and that this MI agent reliably monitors any change in the expression of the targeted protein.
Author Response: We agree that the fact that the standard deviation in the high region is proportional to the signal and at the low end it does not converge to zero has been generally accepted, but we are not aware of the study that systematically verified the linear relationship.
In a fascinating turn, Dudgeon offers the most successful refutation of forgery to date by systematically verifying the diaries' contents, relentlessly revealing and cross-referencing new sources to pull together loose ends and flesh out identities from cryptic references and last names, such as that of Casement's alleged boyfriend: "Millar".
Kyle will be verifying that.
The report placed partial blame for the problems on the Department of Veterans Affairs, saying it has unclear eligibility rules, does not systematically verify financial information and uses forms that do not require applicants to report asset transfers and other financial details.
At the risk of being computationally costly, the discovered informative factors may still need to be systematically examined to further verify that they are not involved in higher-order interactions.
Simulations were carried out on polyalkanes in alcohol co-solvated systems to verify systematically that the OPLS-AA force fields can accurately describe the solvation of low molecular weight polyalkanes with increased alcohol content.
Thus, our results suggest that the effects of alternative mRNA isoforms should now be systematically verified in developmental gene studies.
