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In addition, three different simulation conditions were considered, representing a systematic refinement of the model.
A systematic refinement of ADME properties during lead optimization led to a lead compound with good half-life that was brain penetrant.
Single integral representations for the resistive and reactive components of the radiation impedance appropriate to a rectangular piston are established, thereby enabling a systematic refinement of estimates at both short and long wavelengths.
Systematic refinement of this two-step system using a novel clinical grade medium resulted in a therapeutically applicable cell culture protocol.
To ensure the highest selectivity and sensitivity, a systematic refinement of the selected peptides and transitions can be employed.
Strengths of our approach include our rigorous theory-driven and evidence-based approach to intervention development, our systematic refinement of the intervention based on feasibility and usability data, and our selection of usability assessment techniques.
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Known results, based on a small perturbation or linear approximation, are recovered and the formulation developed enables systematic refinements, outside the scope of linear theory, to be found.
Systematic refinements in binary imaging analysis techniques combined with an algorithmic approach allow for more exhaustive characterization of nerve parameters in the surgically relevant injury paradigms of regeneration following crush, transection, and nerve gap injuries.
The computational modeling is based on the Reynolds Average Navier Stokes (RANS) equations and uses a novel hybrid meshing scheme designed to accurately resolve near field viscous flow features through systematic grid refinement.
As a solution to this problem, systematic model refinements, called completions, hide low-level details from developers.
Progress in airframe-noise simulations appears real, but systematic grid-refinement studies and noise comparisons with experiment or other simulations have yet to occur, and the theoretical uncertainty is high.
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