Sentence examples for systematic mutation from inspiring English sources

Here, we report a technique, termed SyMAPS (Systematic Mutation and Assembled Particle Selection), that can be used to characterize the assembly competency of all single amino acid variants of a self-assembling viral structural protein.

Moreover, the application of systematic mutation profiling to >120 pediatric low-grade astrocytomas reveals a clinically informative molecular stratification not previously recognized in this tumor type.

However, the OncoMap platform may offer one immediate avenue by which systematic mutation profiling might be initiated to guide clinical trial design as well as use of existing targeted agents across many cancer types.

In other studies, systematic mutation screening of genes initially identified through chromosomal, CNV, and/or resequencing analysis has led to the discovery of rare autism-associated variants/mutations in several genes, including NLGN3 and NLGN4 at Xp22.3 [31], NRXN1 at 2p16.3 [15], [32], SHANK3 at 22q13 [33] [35], and CNTNAP2 at 7q35 [36]–[38].

Systematic mutation of Tetraodon GPCRs will help to determine their neural, developmental and behavioral roles.

The publication of data from systematic mutation screens provides a new avenue for COSMIC.

The findings above obtained by analyzing systematic mutations, somatic CNVs, clonal analyses as well as HBV integrations all imply that H-ChC originates from a common progenitor.

Large-scale datasets quantifying the influence of systematic mutations on coiled-coil stability are a valuable new asset to the area.

The Phe34 phenyl side chain situated at the tip of the relatively short sA-sB loop of TIMP-3 extends into a unique hydrophobic groove of the TACE surface, and two Leu residues in the adjacent sC-connector and sE-sF loops are tightly packed in the interface allowing favourable interactions, in agreement with predictions obtained by systematic mutations by Gillian Murphy's group.

The systematic mutations of these types could accelerate the genesis of certain types of SSRs and interrupt others.

A 33-kbp pathogenicity island has been identified in F. tularensis [ 13], and systematic mutations confirmed its key role in virulence [ 14].