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Instead, they insist that both conceiving and testing hypotheses are processes of reasoning and systematic inference, that both of these processes can be represented schematically, and that it is possible to distinguish better and worse paths to new knowledge.
The high-throughput genomic data enable systematic inference of gene regulatory networks (GRNs) [ 1, 2].
We further evaluated the performance of ExTILAR by systematic inference of an in silico network.
This study was divided into two parts and describes: (i) the reconstruction and validation of an expanded S. cerevisiae metabolic network, iMM904; and (ii) the systematic inference of intracellular metabolic states from two yeast EM data sets using a constraint-based sampling approach.
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Large scale analysis of biomolecular networks has proven to be of great utility in offering genuine insights into molecular interactions and construction of systematic inferences.
Indeed, in many cases the incidence of these conditions is correlated because taxonomists are at times misled by convergence in their systematic inferences.
In the chronologically long-lived mutant: sch9Δ, ras2Δ, and tor1Δ, several common stress response transcription factors are activated compared with the wild type according to our systematic transcription inference.
Finally, in Experiment 4, we demonstrate that these systematic visual inferences are unlikely to result from demand characteristics or response biases.
These could always indicate noise resulting from systematic errors in inference, but the high bootstrap values on the DdDp trees suggests otherwise.
Few systematic models and/or inference algorithms have been proposed for the elucidation of regulatory networks from fitness data.
The issues of external validity of randomised controlled trials (and by inference, systematic reviews) have been aired in the context of clinical studies.[ 15, 16].
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