As mentioned earlier, and in part because of the systematic difficulty of measuring PKA activity in vivo, an important supplement is to measure the net effect of PKA activity targeted towards the most relevant substrates (possibly reflecting local PKA activities) by measuring Gli processing.
Considering that the plots of the survey are distributed on a systematic network, some difficulties in this study are related to a non-balanced distribution at the national level of tree species, diversity levels, and ecological factors.
Unfortunately, because of logistical difficulties, systematic data and sample collection and analysis could not be conducted for all case-patients in Bac Giang hospital.
The problem, for now, is incoherence, not systematic persecution.Russia's difficulty in dealing with religious freedom reflects partly a dilemma about whether the country is a secular or a confessional state.
Our purpose was to examine the relationships among items in two-tier multiple-choice (TTMC) items, to compare if there were any systematic differences in difficulty according to tier, according to content, or as a combination of these.
There were some limitations common to most systematic reviews, primarily difficulty in accessing literature not published in English.
Thus, Gentile's taxonomy allows a systematic progression in difficulty of motor tasks and meets the demand of the motor learning principle progression.
Out of fear of political difficulties, a systematic handling of public church law, especially what concerned the relations between church and state, was omitted.
For a systematic discussion of the difficulties in finding an acceptable version of the closure principle, see Hawthorne 2005.
We hope that a systematic knowledge of the difficulties usually reported in scale development will help future researchers to recognize their own limitations and especially to make the most appropriate choices among different conceptions and methodological strategies.
