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The phrase "systematic challenge" is correct and usable in written English
It can be used to describe a challenge that is organized, methodical, or follows a specific system or approach. Example: "The team faced a systematic challenge in implementing the new software across all departments."
Exact(2)
The most systematic challenge has come from Abol-hassan Banisadr (Iranian president, 1980-81).
Former President Bill Clinton opened the Democratic National Convention on Monday with a systematic challenge to President Bush's leadership, using humor and a piercing attack to argue that Mr. Bush had unraveled a prosperous and well-respected nation that Mr. Clinton left him four years ago.
Similar(57)
"There are systematic challenges that will require sustained reforms," Mr. Emanuel told reporters during a tense news conference at City Hall.
Laura Turner, an economics grad student who blogs at Liberalism Without Cynicism, wonders about the usefulness of that dichotomy: Both the New Democrats and Klein's "New New Democrats" are "idealistic, hyper-rationalist, secular technophiles, combining a fierce partisanship … with systematic challenges to industrial-era liberal orthodoxy," she suggests.
I'm very aware of the systematic challenges we face as a people, and the realities of racism and oppression in this country.
The process evaluation revealed a number of systematic challenges.
In addition, phylogenetic analyses of the mitochondrial protein-coding genes yield a fully resolved, well-supported phylogeny, showing promise for addressing systematic challenges in green algae.
Significant systematic challenges to effective delivery of rehabilitation interventions during disaster include a lack of trained responders as well as a lack of medical recordkeeping, data collection, and established outcome measures.
To overcome some of these systematic challenges, PFs had to recognize that each practice was unique and had to tailor approaches and tools accordingly: "one size does not always fit all" [PF2-15].
The results of this case-study, conducted in an exemplary NHS academic research centre, highlight current systematic challenges to patient recruitment and retention in clinical studies more generally as seen from the perspective of staff at the 'sharp end' of recruiting.
Published explanations for these differences are often based on individual-level decisions such as work/life balance preferences or the desire to start a family (Ceci and Williams, 2010, 2011; Rosser 2012), as opposed to systematic institutional challenges.
More suggestions(15)
comprehensive challenge
routine challenge
systematic problem
systematic business
systematic encouragement
methodical challenge
systematic difficulty
consistent challenge
systematic problems
consistently challenge
structured challenge
systematic difficulties
systematic challenges
continuously challenge
systematically challenge
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com