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Sure, Sega and a few others tried to challenge it, but in recent years, the only handheld gaming system of importance has been the Game Boy, and more recently, the Game Boy Advance and Game Boy Advance SP. Suddenly, handheld gaming is seen as the next great gaming battleground.
However, to strictly argue that neither GABA (a neurotransmitter system of importance in the outer retina) nor protons play a role in the communication in the outer retina is unwarranted at this time.
For the sick-listing practice of orthopaedic surgeons, it seems that not only is the way they perceive their role in the health care system of importance, but also their view of how to handle situations in which they disagree with the patient about the need for sick leave.
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In this work, the Group Contribution Equation of State (GCA-EoS) is applied to model several systems of importance in this field.
But most of the complex systems of importance in nature and industry are solutions, particularly solutions that are highly non-ideal in character.
This subcategory describes intra-organizational dynamics and support systems of importance for the managers' experience of legitimacy within the organization in times of media pressure.
Thus, the choice of the agitation system is of importance for the foam potential of the biogas plant.
Researchers could use the expertise of safety practitioners to describe the sociotechnical system characteristics of importance for workplace safety.
But Virchow made cellular pathology into a system of overwhelming importance.
"The very existence of the accounts is a recognition and acknowledgment by Bangladesh Bank and, by extension, the financial system, of the importance of these children's everyday struggles, lives and their work".
Hawaiians can probably feel a bit safer, but of course the big problem is that any of this was possible in the first place with a system of such importance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com