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Utilizing decoupling properties of power system, mutation is implemented.
Although data indicate that HLA status is not the sole genetic factor, only a single case of a functional orexin system mutation has been discovered, in a study with a selection bias designed to increase yield.
In the GFG system, mutation of the AVR genes would allow new, virulent isolates to escape recognition by these new resistance specificities.
The 1 isolate that was negative for all 3 genes carried a single A2059G (Escherichia coli numbering system) mutation in the 23S rRNA gene.
However, in our experimental system, mutation of both K225 and K229 to Arg did not significantly reduce Klf4 acetylation status (Fig. 5C), suggesting that there might be other sites involved in p300-mediated acetylation of Klf4.
Furthermore, this 'axial' difference in the activities of Hox proteins from the starlet sea anemone is also evident in the degree to which they rescue a nervous system mutation in the bilaterian fly, Drosophila melanogaster.
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Importin-α3 function has also been examined in the nervous system: mutations in importin-α3 fail to import a synaptic dSmad2 signal into the nucleus and show defects in proper axonal tiling of photoreceptors [11].
In order to identify which HDACs, if any, were involved in FLO1 gene repression in our system, mutations in various HDACs were prepared and screened for FLO1 transcription.
In addition to genes regulating the immune system, mutations in genes affecting epithelial ER stress and function have been associated with IBD risk factors (Khor et al., 2011).
Vasen et al. [ 55] hypothesized, '...because of the defect in the MMR system, mutations may accumulate in genes involved in the progression of breast cancer.
Although genes with repetitive sequences are clear targets in tumours with a defective mismatch repair system, mutations in non-repetitive sequences are also found in MSI tumours.
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