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The lack of responsiveness of DYT1 patients to L-dopa treatment would be expected if the dopamine D2 receptor signaling or other component of the dopaminergic system is defective in addition to defects in dopamine synthesis.
However, when the system is defective, instead of stopping service completely, the service continues at a slower rate.
In case that the regular steering system is defective, differential steering can be utilized to act as the sole steering power, and thus avoid dangerous consequences for vehicles.
These high-grade extracellular pathogens appeared to neighbour opportunistic bacteria such as Klebsiella and Enterococci, which are characterised by a relatively low propensity to cause disease but a more aggressive behaviour in situations when they reach unprotected sites (blood, tissues) or when the host immune system is defective.
In addition, complement system is defective in CLL patients [ 93].
Release of iron from macrophages in the reticulo-endothelial system is defective, ferritin concentrations are increased, and serum transferrin levels are normal, rather than elevated [ 4].
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The Oklahoma case is the first in which a jury found a Toyota vehicle's electronic throttle control system was defective.
Reeb said the case reminded him of a dispute during the 2000 Olympics in Sydney, Australia, where a Bulgarian rower challenged the results of a photo finish because she claimed the recording system was defective.
Ford, which has long denied that the ignition system was defective or caused any fatal accidents, has settled at least four lawsuits involving serious injuries and at least four deaths.
These images are being reviewed by the Federal Aviation Administration to determine if Frontier's oxygen system was defective, Sallinger said.
Three weeks after the event, the Hart family sued the WWF for causing Owen's death with a poorly planned stunt; they claimed that the harness system was defective.
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