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We used to know one hormonal receptor system in cells.
In addition, high levels of ROS in the muscles can provoke a hyperactivation of the innate immune system in cells such as macrophages and neutrophils [66], and it leads to the production of several peroxides and aldehydes that are potentially toxic to the cells [67], also affecting T cell polarization and contributing to pro-inflammatory cytokine secretion [68].
GSH is the major ROS-scavenging system in cells and the important redox modulating enzymes including the peroxidases, peroxiredoxins and thiol reductases rely on the pool of reduced GSH in the cell as their source of reducing equivalents [18].
This is testified by i) the equal amount of newly synthesized cellular and viral glycoproteins associating with Calnexin, ii) the unchanged kinetics of substrate release from Calnexin and iii) the unperturbed maturation of HA (an obligate client of the Calnexin chaperone system) in cells with low, normal or elevated levels of Malectin.
If this is the case, what is the role of the GSH GSTs system in cells?
Importantly, MIA40 requires AIF for the physiological protein availability and function, resulting in an altered OXPHOS system in cells lacking AIF.
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Finally, by proposing a simple dynamic clustering method, the performance of system in cell-edges can be noticeably improved.
Consequently, development of mouse models with dominant negative Trx1 or an NF-κB reporter may enhance further understanding of redox control system in cell nuclei in vivo.
The implication of the endocannabinoid system in cell proliferation, differentiation and survival is now well recognized.
In addition to being an important pathogen T. brucei has developed into a model system in cell biology.
Interestingly, pFab out-performed the parent pUC19-ampicillin system in cell growth, plasmid stability and plasmid yield.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com