Sentence examples for system for mechanistic from inspiring English sources

These data support a luminal multilineage progenitor cell model for prostate tissue and establish a robust, scalable system for mechanistic studies.

Another valuable model system for mechanistic studies of myogenic differentiation is the mouse ES cells.

One valuable model system for mechanistic studies of early development is the pluripotent P19 cell line.

The copper transport ATPase from Thermotoga maritima (CopA) provides a useful system for mechanistic studies, due to its heterologous expression and stability.

It may also be that further evolution of such alternative strategy required dismantling of the MHC II system for mechanistic reasons and thus caused a selection pressure against its presence.

To confirm the impact of EpCAM on breast cancer invasion in vivo, and to establish a functional rescue/gain-of-function model system for mechanistic studies, we generated stable breast cancer cell lines with specific ablation of EpCAM expression using EpCAM-specific lentiviral shRNA constructs.

For example, although many RNA degradation pathways, enzymes, and cofactors have been identified, a precise understanding of their biochemical function and mechanisms of action will need further experimentation, including the development of robust in vitro systems for mechanistic studies.

These data demonstrate that the formation of hPSC-derived cortical networks mimics in vivo cortical network development and function, demonstrating the utility of in vitro systems for mechanistic studies of human forebrain neural network biology.

While 'triculture' models that include pericytes (Nakagawa et al., 2009) may show some useful additional properties (Al Ahmad et al., 2011; Ramsauer et al., 2002), endothelial-astrocyte models can show a BBB phenotype close enough to the in vivo situation to make more practical systems for mechanistic studies and permeability assays.

Thus, although animal and cell culture studies provide controlled model systems for mechanistic studies of As, it is critical to understand which of these findings translate into cellular, molecular, and clinical effects in actual human exposure situations, and the role of these in pathophysiologic processes such as carcinogenesis.

The failure of mouse XPA model calls for a relevant human model system for disease mechanistic studies.