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Gruss, currently head of the department of molecular cell biology at the Max Planck Institute (MPI) for Biophysical Chemistry in Götingen, studies genes that control the development of the nervous system, eye, and pancreas.
In contrast, mouse Lbx2 is not expressed in these regions, rather labelling the urogenital system, eye and brain [ 19].
Special focus was given to those organs which are mainly affected in diabetes like cardiac system, renal system, eye and brain.
In vertebrates, SOX proteins have been shown to have essential roles in the formation of many body systems including the central nervous system, eye and heart development, bone cartilage, vasculature, sex determination and testis development [ 10- 14].
The teratogenic consequences were evident as dysmorphology of various organs (central nervous system, eye, and heart) that involved pathogenic effects beyond just the observed delay of the normal course of development.
In addition, the expression pattern of mammalian Lbx2 is distinct from that of Lbx1 (Lbx2 is expressed in the urogenital system, eye and brain) [ 19], whereas the two chicken Lbx genes and all zebrafish genes are co-expressed in migratory muscle precursors (K. R. Wotton and S. Dietrich, unpublished data).
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A study found that cholinesterase inhibition was associated with symptoms from the respiratory system, eyes and central nervous system among farmers [ 14].
It is characterized by multiple hamartomas and neoplasms of ectodermic, endodermic and mesodermic origin affecting skin, oral mucosa, gastrointestinal tract, bones, central nervous system, eyes and genitourinary tract.
It is characterized by multiple hamartomatous neoplasms of the skin and mucosa, gastrointestinal tract, bones, central nervous system, eyes and genitourinary tract.
The infective larvae then penetrate into the intestinal wall and are carried by blood circulation to many organs including lungs, liver, central nervous system, eyes, and muscles [ 1].
Alagille syndrome is a multisystem disorder, which is characterized by hypoplasia of the intrahepatic bile ducts, malformations of the cardiovascular system, eyes, and vertebral column, and abnormal facies.
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