Sentence examples for synthetic switch from inspiring English sources

The refined recombination procedure allowed efficient construction of a single copy of a complex genetic circuit in cells, and the resultant reduced fluctuation in copy number led to accurate phenotypic behaviour of the genome-integrated synthetic switch corresponding to the design principle.

Previously we described a synthetic switch in which an RNA binding protein represses the translation of a target mRNA.

These synthetic switches are capable of a highly specific regulatory response both in vitro and in vivo.

Synthetic switches have been built both in bacterial [18] and mammalian [19] cells for a variety of applications (e.g. gene therapy, construction of bio-sensors and research tools).

However, previous studies of a synthetic toggle switch have shown that the noise-induced state switching is a rare event [ 15, 34, 35].

First we would like to note that while the majority of our findings focus on the synthetic toggle switch system, we also replicated our findings in the GAL network in yeast and the lactose switch in E. coli.

Gardner et al. used two transcriptional repressors to construct a synthetic toggle switch genetic regulatory network in Escherichia coli also in 2000 [31].

In this paper, we develop a new methodology to design synthetic genetic switch networks with multiple genes and time delays, by using monotone dynamical systems.

Finally, to demonstrate our theoretical results, we show biologically plausible examples by designing a synthetic genetic switch with experimentally well investigated lacI, tetR, and cI genes for numerical simulation.

Negative feedback between simple switches can lead to bistable response, as observed in Delta-Notch signaling [ 4] and used to create a synthetic toggle switch [ 5].

Here we use an RNA/protein interaction-based synthetic translational switch to create a feedback system that tightly controls the expression of proteins of interest in mammalian cells.