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However, their compounds require multiple synthetic steps.
Dendrimers form nanometer by nanometer, so the number of synthetic steps dictates their exact size.
Despite their importance, current approaches mostly necessitate laborious synthetic steps employing pre-functionalized starting materials under demanding conditions.
This minor change reduced the total number of synthetic steps from 14 to 7.
The title compounds were prepared using benzotriazole as the synthon, through several synthetic steps.
The key synthetic steps involve a Meinwald rearrangement and a palladium-catalyzed carbonylation reaction.
The compounds were obtained using two synthetic approaches for reducing the synthetic steps as well as improving the yield.
Significantly, target molecules were accessed in just two synthetic steps, suggesting further optimization will require minimal synthetic effort.
The key synthetic steps involve a Michaelis Arbuzov reaction followed by coupling with uridine-5′-morpholidophosphate as activated UMP derivative.
However, the chemical synthesis of these chiral intermediates have the disadvantages of low enantiomeric purity and complex synthetic steps.
Straightforward synthetic steps, starting from amino acids, allow the facile construction of a wide range of analogs.
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