Sentence examples for synthetic specific from inspiring English sources

In order to investigate MMP-13 specificity, RS 110 2481 (a synthetic specific MMP-13 carboxylate inhibitor generously provided by C Myers [Roche Bioscience, Palo Alto, CA, USA]) [ 37], was used.

We also provided evidence of involvement of GSK3β in the upregulation of Hsp70 by using LiCl, known to be a classical inhibitor of GSK3β and the synthetic specific inhibitor SB216763.

To elute the complex, beads were incubated for 2 h at 4°C and another 10 min at room temperature with the synthetic specific peptide (c-myc: H-EQKLISEEDL-NH2, Roche Diagnostics, Basel, Switzerland) and the scrambled nonspecific peptide (cym: H-IELQKELDES-NH2, jct, Berlin, Germany) respectively.

A synthetic specific inhibitor for p38 MAPK, SB203580, eliminated the activation of this kinase in EMD protein-stimulated MG-63 cells, further indicating the activation of p38 MAPK in MG-63 cells in the presence of EMD protein.In order to further characterize the role of EMD protein-induced p38 MAPK pathway activation, MG-63 cells were pretreated with SB203580, followed by EMD protein stimulation.

Its contribution to tumour expansion in the lungs has been also assessed using animal models and synthetic-specific CXCR7 ligands.

The treatments with synthetic-specific CXCR7 ligands were delivered to mice by intraperitoneal injections of 100 mg kg−1 of the CCX771 compound or its early prototype, the CCX754 compound (Burns et al, 2006; Zabel et al, 2009), according to preventive or curative treatments as described below.

The last two are synthetic substrates specific for trypsin- and chymotrypsin-like proteases, respectively.

Amidolytic assays involve synthetic peptides (specific peptides for a particular substrate), which are mostly tripeptides or quadrapeptides linked via an amide bond to a fluorophore/chromophore such as para-nitroaniline (pNA).

Consistent with this observation, treatment with a synthetic inhibitor specific for myosin II, Blebbistatin [45], led to remarkable cell-cell disintegration emulating the phenotype observed in the loss of function of Rho or Rock (Figure 4D).

For example, the approved drug Arixtra is a synthetic and specific inhibitor of activated factor X (Xa) indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism.

In this experiment, EcR293 cells expressing the dEGFP transgene were transfected with DualU6GFP in the presence and absence of the synthetic siRNA specific for Dicer.