Achieving these materials will require the development of new synthetic methodologies and strategies.
The tremendous progress achieved in therapeutics is rooted in enabling synthetic methodologies and strategies to assemble ever more sophisticated and effective molecules.
Full synthetic methodologies to obtain racemic CAI-1, based on the synthesis of deuterated CAI-156, are described in the Supplementary Methods.
Brown, D. G. & Boström, J. Analysis of past and present synthetic methodologies on medicinal chemistry: where have all the new reactions gone?
Synthetic methodologies and SARs of this series of compounds are described.
Therefore, various synthetic methodologies have been reported to access these backbones.
At the core of these efforts is the development of new synthetic methodologies to provide flexible, efficient, systematic access to these structures.
Calabrese D, "Synthetic methodologies and characterization of small molecules and polymers for surface modification," Ph.D. Thesis, Cornell University, Advisor: David Collum (2015).
Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials.
Starting from 5, the synthetic methodologies employed permitted us to perform a rapid and a convenient divergent synthesis.
In addition, new asymmetric syntheses and other synthetic methodologies are often important in preparing the designed compounds.
