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Hanjaya-Putra, D. et al. Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix.
The ability to harness the regenerative potential of stem cells via a synthetic matrix has promising implications for regenerative medicine.
This paper describes the rheological properties of silated hydroxypropylmethylcellulose (HPMC-Si) used in biomaterials domain as a three-dimensional synthetic matrix for tissue engineering.
The properties of an injectable chitosan (CS /methylcellulose (MC) blend hydrogel used as a three-dimensional synthetic matrix for tissue engineering were investigated.
Biphasic character and hydrophilicity of polyurethanes with gel like architecture provide a synthetic matrix conducive for chondrogenesis of MSCs, as evidenced by deposition of cartilage-associated extracellular matrix.
This pilot study was designed to assess whether a synthetic matrix metalloproteinase (MMP) inhibitor has anti-inflammatory properties in mild asthma.
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Enemchukwu, N. O. et al. Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis.
Among natural and synthetic matrices, collagen and polysaccharidic biomaterials have been extensively used with promising results.
These data highlight the potential of synthetic matrices to steer stem and progenitor cell behavior via defined mechano-adhesive properties.
Specific areas of interest include microfluidic devices to study neuronal chemotaxis and neurite guidance within gradients, synthetic matrices for three-dimensional neural cultures, and injectable hydrogels to deliver cells, proteins, and drugs to the central nervous system.
This is achieved through the development of tunable, synthetic matrices with control over their hydrophobicity without altering the chemical and mechanical properties of the matrix.
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