"synthetic difficulty" is correct and usable in written English.
You could use it to describe a challenge that is artificial or created specifically to test a person's skills. For example, "The students faced synthetic difficulty during the simulated job interview exercise."
In spite of these benefits, the synthetic difficulty and complex surface structure associated with polymer brushes have hindered their utilization for constructing multifunctional, patterned surfaces.
Many crucial factors must be considered, including: chemical stability, synthetic difficulty, chemical complexity and diversity, ADMET properties, cost, chemical novelty and intellectual property issues, and 'biological appropriateness'.
While these elegant approaches to creating cell-laden hydrogels with bio-orthogonal chemistries give researchers powerful tools with which to interrogate the roles of biological signals in the cellular microenvironment, their impact on the biomaterials field has not yet been fully realized because of the synthetic difficulty associated with strained cyclooctyne molecules required for SPAAC.
These synthetic difficulties have been overcome in the present study by the use of modern living polymerization techniques.
Due to their complex chemical structures and synthetic difficulties, the structure activity relationships (SARs) of them are still limited.
The synthesis of the 'DPEN'-derived ligand threw up several synthetic difficulties preventing the isolation of pure ligand, but the crude ligand was converted into its Ru complex that was then purified using column chromatography and fully characterised (Scheme 3).
Synthetic difficulties that currently prevent the general incorporation of NHCs into chelate, pincer and tripod ligand architectures are related to the inability of the NHC to reversibly decoordinate to correct binding 'errors' in the initial kinetic products of NHC complex formation.
These synthetic difficulties led to the investigation of other halide/metal exchange conditions.
During this study, many stereochemical and synthetic difficulties were solved and the Baldwin principle was updated.
We recognized the synthetic difficulties of caged xanthenes are inextricably linked with the fluorogenic mechanism of the dyes.
Since the open closed equilibrium is both the basis for fluorogenicity and the cause of synthetic difficulties, we envisioned eliminating this process in a reversible manner.
