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The detection method presented in this article is a candidate for in vivo single-molecule detection and, through parallelization in a synthetic device, for genotyping and global transcription profiling from small samples.
The results showed that the synthetic device can mimic biological uptake in the presence of humic acids, nitrate, sulfate, and phosphate, and pH within the range 5.5 9 when S. acutus was used as the biological reference, considering the simultaneous contribution of the Zn2+ and ZnOH+ labile species depending on the chemical composition of the medium.
Because of the limited number of CID systems at hand our synthetic device can only generate a single output for probing signaling pathways like Rac.
Daringer et al. recently reported a synthetic device in mammalian cells that senses extracellular ligands through ligand binding-induced dimerization, which releases an orthogonal transcription factor that is independent of native cellular components.
Recently a simple synthetic device was engineered in a cell, and several cells were then combined, so that their connections allowed the construction of a more complex synthetic gene circuit, i.e., so-called multi-cellular engineered networks.
In our study, the Rac signaling pathway as a whole served as a YES gate and enabled us to engage a synthetic device with an endogenous signaling circuit in order to execute a biologically relevant output.
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The most common procedure is replacement of the working parts of the knee with synthetic devices of metal and plastic or ceramic materials that can withstand normal stresses on this weight-bearing joint for at least a decade.
Because cartilage contains a unique structure, it is difficult to mimic by synthetic devices.
The role of synthetic devices in the management of the cruciate ligament injured knee remains controversial.
The aim of this systematic review was to assess the safety and efficacy of synthetic devices in cruciate ligament surgery.
The introduction of synthetic devices that provide precise fine-tuning of transgene expression has revolutionized the field of biology.
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