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Here, we discuss recent advances and ongoing efforts in designing and characterizing synthetic compartmentalization systems to mimic natural strategies and increase metabolic yields of engineered pathways.
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The technologies can be broadly divided into three categories according to their spatial segregation strategy: (1) cells as reaction compartments, (2) in vitro compartmentalization via synthetic droplets, and (3) microchambers.
Well-established approaches for the development of synthetic cell-free enzyme pathways include micro-compartmentalization, ionic channeling, co-polymerization, and protein fusion.
This is relevant to the origins of life, as well as synthetic life studies, because it supports current thinking that the compartmentalization is one of the very basic characteristics of any cell [ 259- 261], no matter how primitive or minimal it may be.
"Synthetic biology".
Synthetic linings.
Nothing synthetic".
But in recent decades such compartmentalization has disintegrated.
Synthetic viruses?
Synthetic life.
What about synthetic oil?
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