Synthesized based evaluation of the proposed designs is reported.
Novel N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3 N- benzo[d]thiazol-2-ylcarbamoyl -2-methyl-4-oxoquinazoline-3
New ferrocenyl derivatives with the general formula FcC(O L [Fc = (η5-C5H5 Fe η5-C5H4 ], where L is an aminoquinoline or hydroxyaminoquinoline, have been synthesized for evaluation of their leishmanicidal properties.
A new type of 4,5-diaryl-4H-1,2,4-triazole, possessing C-3 thio and alkylthio (SH, SMe or SEt) substituents, was designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo anti-inflammatory activity.
In an attempt to prepare a new water-soluble, parenteral COX-2 inhibitor, rofecoxib (9) and celecoxib (13) analogues were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo anti-inflammatory activity.
A group of PEH analogs, possessing a variety of substituents (Me, OMe, Cl, F, and CF3) at the 2-, 3-, and 4-positions of the phenyl ring, were synthesized for evaluation as inhibitors of GABA-T.
A new series of 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives 10a-h was designed and synthesized for evaluation as selective COX-2 inhibitors, anti-inflammatory agents and as analgesic agents.
A new type of 1-aryl-5- 4-methylsulfonylphenyl)imidazoles, possessing C-2 alkylthio (SMe or SEt) substituents, were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo anti-inflammatory activity.
N-Acetyl-2-carboxybenzenesulfonamide (11), and a group of analogues possessing an appropriately substituted-phenyl substituent (4-F, 2,4-F2, 4-OCHMe2 4-OCHMe2) atoached to its C-4, or C-5 position, were synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors.
A group of 1,3-diarylurea derivatives, possessing a methylsulfonyl pharmacophore at the para-position of the N-1 phenyl ring, in conjunction with a N-3 substituted-phenyl ring (4-F, 4-Cl, 4-Me, 4-OMe), were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors.
