We predicted the expected synthesis outcome based on all the P-O bonds in POCl3 breaking and the total amount of oxygen-18 (73.0%) and oxygen-16 (27.0%) contained in the synthesized OLP, (Table 4).
Even when time and effort is invested in quality appraisal systematic review authors rarely comment on the credibility, rigour of conduct or the contribution the different studies make to the synthesis outcome.
Results of the quantitative data synthesis of outcomes post-treatment are presented in Table 2.
Using an evidence synthesis, the outcomes from the included interventions were synthesized and conclusions were drawn about the level of evidence for the effectiveness of interventions within each target.
31 32 The data extracted will include all details specific to the review question and fulfils the requirements for both the narrative synthesis of outcomes and the potential meta-analysis.
11 For other outcomes, we summarised the results in tables and did a qualitative synthesis.
Qualitative syntheses for outcomes were provided whenever possible.
Synthesis of outcome data through meta-analysis is appropriate provided there are sufficient relevant and valid data that use measures of outcome that are comparable".
Although BMP-2 induced an increase in proteoglycan synthesis, the outcome in proteoglycan content was comparable to the natural reparative response.
The phenomenon of "publication" bias has been well described for the biomedical literature and has been identified as a major threat to reliable syntheses of outcomes research [ 36- 40].
