Sentence examples for synthesis of active from inspiring English sources

Conversely, hypoxia dramatically affected gemcitabine activity, reducing the synthesis of active gemcitabine deoxynucleotides, possibly also through downregulation of the rate-limiting enzyme dCK.

PTH regulates the calcium und phosphate homeostasis by activating osteoclasts and osteoblasts, enhancing intestinal Ca2+ absorption, promoting the synthesis of active vitamin D in the kidney and increasing active renal Ca2+ reabsorption.

The synthesis of active Klebsiella aerogenes urease via an 18-subunit enzyme apoprotein-accessory protein pre-activation complex has been well studied biochemically, but thus far this complex has remained refractory to direct structural characterization.

These case studies involve multiphase reaction systems for the synthesis of active pharmaceutical ingredients.

Chiral epoxides are commercially important starting materials for synthesis of active pharmaceutical ingredients and agrochemicals.

Unfortunately, the synthesis of active metal complexes may be limited to very small number.

Here, we describe the total chemical synthesis of active-site-directed probes and their application to activity-based profiling and identification of functional DUBs.

Linear chemical synthesis of active-site directed Ub-based probes Method A (for probes 1, 3, 4, and 5 ): The Ub(1 75) peptide sequence with a free N terminus but with side chains protected, was synthesized (25 μmol scale) on a trityl resin by following Fmoc solid-phase peptide synthesis procedures as described, 12 with minor modifications.

In men, the prostate is the major peripheral tissue where STS activity contributes to the local synthesis of biologically active androgens.

Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.

Such (b) approach is difficult as the target of PZQ still unknown, the synthesis of new active analogues is possible from delineation of structure-activity relationships for PZQ.