We highlight the importance of conceptual models in the design and evaluation of interventions, and present a synthesis of current models of access of relevance to common mental health problems in the United Kingdom.
The modular nature of the designed synthesis allowed access to a series of novel inhibitors through derivatisation of a late-stage intermediate.
The utility of the technique is further demonstrated through the synthesis of block copolymers, enabling access to a new field of well-defined UHMW materials.
Recently, important new methods developed by Devaraj and co-workers have paved the way for the efficient synthesis of tetrazines, providing easy access to many substitution patterns.
'Candidacy' is a concept derived from an interpretive synthesis of literature pertaining to access to health care by vulnerable groups in the United Kingdom [ 11].
We illustrate this briefly using an example based on synthesis of the literature on access to healthcare in the UK by socio-economically disadvantaged people.
Our critical interpretive synthesis of the literature on access to healthcare by socio-economically disadvantaged people in the UK included 119 papers.
By innovating with existing methods for interpretive synthesis, it was possible to produce not only new methods for conducting what we have termed critical interpretive synthesis, but also a new theoretical conceptualisation of access to healthcare.
This expansion involves new methods of synthesis that provide access to novel polymer architectures, and materials with useful combinations of properties that include superhydrophobic surfaces, biomedical materials, responsive membranes, photonic materials, battery electrolytes, fuel cell membranes, fire-resistant polymers, and new systems that generate micelles, stars, and dendrimers.
We are currently developing a convergent synthesis of compound 11, allowing synthetic access to the molecule itself, as well as analogues for optimisation.
