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In music, he was a devotee of Duke Ellington, "the pre-eminent embodiment of the blues musician as artist", who achieved "the most comprehensive synthesis, extension and refinement to date of all the elements of blues musicianship".
Here, we report the functionalization of one of these peptide scaffolds, RAD16-I (AcN RADARADARADARADA CONH2), by direct solid phase synthesis extension at the amino terminal with three short-sequence motifs.
After translesion synthesis, extension is required.
Recently a class of designer self-assembling peptide scaffolds has also been functionalized directly through solid-phase synthesis extension at the C-termini with short sequences including bone marrow homing motifs.
Here we report the functionalization of the RADA16 self-assembling peptide scaffold RADA16 (AcN–RADARADARADARADA–CONH2) through direct solid phase synthesis extension at the C-termini with three short motifs from the osteogenic growth peptide OGP, the Osteopontin cell adhesion motif described above, and a designed 2-unit RGD binding sequence (PRGDSGYRGDS).
Similar(55)
We need an Extended Synthesis, using "extension" metaphorically.
To determine whether the phthalocyanine derivatives binding to G-quadruplex enhance the block to DNA synthesis, primer extension reactions were carried out in the presence of phthalocyanines.
FAS and ACC are the key enzymes of chain fatty acid synthesis and extension (Tanos et al. 2012), and SCD1 is the rate-limiting enzyme that catalyzes the biosynthesis of saturated to monounsaturated fatty acids (Poudyal and Brown 2011).
As a synthesis and extension of our recent work (Yuan and Wood, 2018), this paper aims to raise more awareness and promote more discussion on the mechanically, chemically, biologically and thermally induced damage issues associated with enhanced oil recovery processes, by integrating the state-of-the-art modelling, laboratory experiments and field applications.
Telomerase functions as an intracellular reverse transcriptase that catalyzes the synthesis and extension of telomeres [ 3].
In the light of the elongated, bilobal shape of Pol α's 3D architecture described here, association of the primase with the lobe occupied by the CTD B raises the question of how the catalytic activities of RNA primer synthesis and extension can be coordinated over the considerable distance separating the two catalytic subunits in the Pol α/primase complex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com