Complexing may be required to fulfill a basic function (e.g., proper binding of tumor necrosis factor) or to synergize activity through, for example, altered binding affinities.
As occurs in women with the polycystic ovary syndrome, there are theoretical bases to suggest that an insulin-mediated overstimulation of ovarian steroidogenesis may occur in females with abdominal obesity, as insulin acts as a true gonadotropic hormone, synergizing LH activity.
Therefore, we can speculate that the radiation therapy to the brain might have enhanced the efficacy of the targeted drugs by either synergizing antitumor activity with the drugs or simply allowing better drug penetration to and accumulation in the CSF [ 22].
The Alzheimer's Association compiles this annually updated compendium to centralize this inventory of partnerships in an effort to synergize these activities.
Use a Social Media Management tool to synergize activity across other social networks.
In addition, many of these novel approaches are being developed both in monotherapy and as part of combinatory regimes in order to synergize their activity.
Increase in curing temperature synergized catalyst activity resulting in loss of tensile strength.
Because the processed form of BT-CryIIA was used in this study, Mir1-CP probably synergized the activity of Bt-CryIIA, by increasing PM permeability and facilitating toxin movement to the microvilli.
It was found that phospholipids synergize the activity of α-tocopherol only in the presence of small amounts of water and catalysis by water-soluble radical generators 54.
The obtained results suggested that MSM synergized the activity of Tam in the drug combination by inhibiting the STAT3 molecule and its phosphorylation both in vitro and in vivo.
The authors conclude that 17β-estradiol seems to contrast, but testosterone seems to synergize, LEF activity, and these results might support the observations that a less effective therapeutic effect in women with RA is due to the action of estrogens [ 28].
