The phrase 'synergize to increase' is a correct and usable phrase in written English.
You can use it when referring to a collaborative effort to reach a greater outcome or result. For example: "By synergizing our efforts, we were able to increase our profits significantly."
This led us to propose a model for the evolution of these two repeated sequences and how they can synergize to increase genome size.
They synergize to increase collagen synthesis by dermal fibroblasts or glycosaminoglycans synthesis by lung fibroblasts, and they are tightly involved in the inflammatory response during septic shock [ 32, 33].
Although the binding affinity of each bromodomain with each acetylated lysine is generally weak, it is believed that it has major functional relevance in the cell, due in part to some proteins possessing more than one bromodomain in tandem that synergize to increase binding affinity, and also due to histones possessing multiple acetylated residue that can act combinatorially.
In this scenario, class 2 mutations would enhance the simultaneous engagement of the membrane by the PIP2- and PA-binding pockets of the PH domain and the positively charged surface of the HF domain, synergizing to increase the stability of SOS1 translocation at the membrane and catalytic activation.
Consistent with our findings, only alanine (data not shown) was able to synergize with inosine to increase the germination rate.
Indeed, four additional compounds were identified that synergize with QMP to increase the retinue response, but even those nine compounds do not elicit as robust a response as a live queen [17].
The observation that glucose appeared to synergize with palmitate to increase ATF3 protein expression, although this was not statistically significant, was consistent with the previous finding by Hartman et. al. demonstrating that high glucose and FFA together increased ATF3 mRNA expression, and that this was associated with increased apoptosis of insulinoma cells [25].
2-methoxyestradiol (ME), an endogenous metabolite of estradiol, can synergize with taxol to increase JNK activation and enhance the apoptotic effect of this chemotherapeutic agent [ 56].
IL-6 is found in ER positive tumors and is thought to synergize with estrogen to increase ER transcriptional activity [ 19, 21], while IL-8 is inversely correlated with ER expression [ 23].
Although B6 may not directly synergize with leucine to increase fatty acid oxidation in muscle cells (Supplementary Figure 1D), it exerts synergistic effects with leucine in adipocytes, serving to both inhibit lipid storage 8 and synergistically increase fatty acid oxidation.
IL-17A could not synergize with TNF to increase osteoclastogenesis and its synergy with RANKL was blocked by OPG, further confirming the fact that it is a RANKL-mediated effect.
