The major TH2 cytokine, IL-4, that was initially reported to synergize with TGF β in order to induce IL-9 in CD4+ cells [ 83] appears to be but a second signal for the generation of TH9 [ 82].
Expression of TREM-1 may be under the control of nuclear factor-κB (NF-κB; activated by the TLRs), with engagement of TREM-1 possibly leading to activation of several transcription complexes that synergize with NF-κB in order to elicit transcription of proinflammatory genes.
Binding of its ligand is possibly linked to the activation of several transcription complexes that synergize with NF-κB in order to elicit transcription of genes of pro-inflammatory cytokines [ 8]. sTREM-1 is the soluble counterpart of TREM-1 and it is probably shed in the systemic circulation from cell membranes of neutrophils and monocytes [ 7, 33, 34].
In addition, many of these novel approaches are being developed both in monotherapy and as part of combinatory regimes in order to synergize their activity.
Four novel scaffolds consisting of total 24 compounds (1a 1o, 2a 2c, 3a 3c and 4a 4c) bearing aromatic sulfonamide and coumarin moieties connected through various linkers were synthesized in order to synergize the inhibition potential of both the moieties against four selected human carbonic anhydrase isoforms (hCA I, II, IX & XII).
Cartoon illustrating the Triple Helix model depicting how academia, biotech industry (SME), and pharmaceutical industry may work close together in order to synergize development of novel regenerative medicine applications for the improvement of human health.
On an international scale, community-based groups in different countries who find themselves fighting similar environmental problems can unite in order to synergize their efforts.
We demonstrate that another function of mitochondrial fusion proteins is to electrically couple individual mitochondria in order to synergize their metabolic activity.
Therefore, PARP-1 could synergize with different transcription factors in order to stimulate or repress gene expression in both stimulation conditions.
(3) the improved time-efficiency of EAF-MR optimization algorithm for a large-scale RF-FPGA: in the EAF-MR algorithm, the EAF optimization synergizes with the multi-resolution method in order to improve the time efficiency of the optimization process in a large-scale RF-FPGA. .
