In this work, we report a novel method, called NIMS (Network target-based Identification of Multicomponent Synergy), to address the network target-based virtual screen and assess the synergistic strength of multicomponent therapeutics.
By using the Bliss independence model [ 5], the synergistic strength was determined by calculating: MIIR= max IR syn– IR add), where IR syn and IR add denote inhibition rates and the Bliss additive value of an agent pair at a certain dose/ratio.
Every dimension of merit must be witnessed in order to be appreciated, and any single behavior can reveal precious details about a partner-competitor's synergistic strengths and weaknesses in one or another domain; hence the permanent necessity of vigilant synergistic who's who learning and synergistic self-promotion (who's who teaching), upstream from mere technical (what's what) learning.
It is found that the wear resistance of BMGs is dominated by synergistic effects of strength factors, namely the hardness (H), Young's modulus (E), yield strength (σy) and glass transition temperature (Tg), as well as toughness factors, like the notch toughness (KQ) and Poisson's ratio.
More importantly, the combined addition of MS and NS has significant synergistic effects on strength and microstructure.
Hybrid staggered architecture composites, like nacre and bone, are known for two discernible aspects: superior strength and synergistic toughness.
Results show that the penetration depth, crater area and penetration damage were decreased greatly by the synergistic effects of high strength fibers and coarse aggregates.
Most notably, costal chondrocytes show a beneficial response to TGF-β1, C-ABC, and HP individual treatments, and a synergistic increase in tensile strength and collagen content in dual C-ABC/TGF-β1 treatment.
In order to determine how these players function together, we first investigated whether they formed a single genetic pathway or defined several pathways by determining whether their inactivation had synergistic effects on barrier strength.
The model proposed by Segal et al. (2008) additionally includes one parameter per TF, describing the strength of synergistic effects, as well as the PWMs as free parameters, greatly increasing the total number of free parameters.
The biggest surprise was the strength of the synergistic punch from the pesticides diazinon and malathion, which killed all the salmon exposed to them.
