Multiple studies have also confirmed the correlation of ETS re-arrangements with PTEN inactivation as synergistic steps in the development of prostate cancer (Chen et al, 2005; Carver et al, 2009; King et al, 2009; Steurer et al, 2014).
Interestingly, a two-step synergistic model was proposed to explain the interaction and activity of progesterone receptor and NFI [45].
For all significant gene-social/behaviour interaction terms (i.e., synergistic association) discovered in Step 1, one uses Chi-squared test (for discrete social/behavioural factors) or the ANOVA model (for continuous social/behavioural factors) or the multiple regression model adjusted for relevant covariates to detect whether the rGE exists.
The enhanced exchange current density of the hierarchical nanostructures can be mainly ascribed to the increase of specific surface area, the nanometric "steps", and the synergistic effect of nickel and cobalt atoms.
The use of Fiber-Reinforced Polymer (FRP) composites takes this one step further enabling the synergistic combination of reinforcing fibers, with appropriate fillers/additives, in a polymeric resin matrix.
Thus, identification of context-dependent miRNA-mRNA modules is an important step to elucidate their synergistic effect on the pathogenesis of complex diseases.
To estimate the association of GxE with health outcome, adjusted for the potential correlation of rGE, we further develop and empirically test in this article an innovative three-step procedure which combines standard regression and structural equations methods, based on ideas raised (not tested) in our previous publication [ 47]: Step 1: Estimate the synergistic association.
Therefore, we hypothesized that there was a significant synergistic reinforcement effect among the three-step genetic engineering in the induction of cellulolytic gene expression in P. oxalicum.
Therefore, it is likely that step-like responses elicited by synergistic action of 10 µM choline and 2 5 µM PNU-120596 result from openings of individual α7* nAChR ion channels detectable in whole-cell patch-clamp experiments.
