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RANTES activation by viral infection has been reported to be regulated by synergistic activity between interferon response factors, IRF-3, IRF-7 and NF-kB in various cell lines [ 28] and by IRF-1, which can bind to RANTES promoter in mouse macrophages [ 29].
An isobolographic study design was employed to assess a potential synergistic activity between GGTI-2133 and FTI-276.
Here we report synergistic activity between E1 and CelA in vitro and in vivo.
This revealed a synergistic activity between the vaccine and chemotherapies in both cases.
Synergistic activity between HSP90 inhibitors and proteasome inhibitors have been observed.
Remarkably, synergistic activity between HDAC6 and proteasome inhibitors [ 21], and HDAC6 inhibition and taxanes [ 71] has been described.
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"This all of a sudden opens up a much richer set of synergistic activities between phones and devices — whereas right now, your phone doesn't really have any clue what is going on around it or what functionality it should reveal)," he adds.
It is difficult to predict synergistic activities between different antimicrobials by studying them individually.
The synergistic activity observed between 9EA-FC-B and ampicillin against MRSA was shown to be associated with inhibition of PBP2a.
Also Tofani et al. [ 35] explained the synergistic activity observed between ELF-MF exposure and cisplatin by hypothesizing its ability to influence free radical chemistry exerted by the ELF-MF treatment.
The synergistic activity found between cisplatin and 5FU prompted the evaluation of the combination of both agents in a phase I, disease-directed study in 21 patients with recurrent HNSCC; the recommended doses were cisplatin 100 mg m−2 on day one of a 21-day cycle, and capecitabine 1000 mg m−2 bid days 1 14 (Pivot et al, 2003).
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