The individual anaesthesiologist's handheld synchronizes patient data daily with anaesthesia database center.
Unfortunately the 'logistics of the ward' – that is the organizational routines of drug rounds and routines of observation rounds – meant these activities were often not synchronized and patients were assessed and data entered in the chart not consistently before (or after) medication.
Three guiding principles were established before the study was designed: (1) work toward synchronizing all patients with medulloblastoma under one study for future biology-based stratification; (2) improve the survival rate with minimal additional adverse effects and reduced long-term sequelae; (3) replace toxic agents with treatments that are less toxic yet still effective.
Patients with low SD (multiple/similar sized lesions) were assumed to have synchronized growth, whereas patients with high SD were assumed to have unsynchronized growth.
Finally, while all ventilators were able to synchronize with patient's demand at baseline (leakage <1 L min−1), only one showed adequate patient synchrony at high leakage level.
Second, knowing these differences may help surgeons and nurses to understand each other's care intensity criteria, and better synchronize their patient care.
The ideal supply chain will synchronize aggregate patient-level drug demand with the flow of pharmaceuticals from suppliers, reducing inventory investment along the chain, and improving patient care by minimizing supply shortages.
For this to occur, however, the ventilatory's flow and pressure delivery must synchronize with patient effort during all three phases of breath delivery: breath initiation, flow delivery, and breath termination (cycling).
In the earliest stages of acute respiratory failure, maintaining respiratory muscles at rest, in particular the diaphragm, is frequently performed, the better to synchronize the patient and the ventilator.
