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We performed 14 to 19 consecutive daily intravitreous injections of a potent cholinergic agonist, epibatidine (Epb) which completely blocked synchronized activities with bath application [25], [26], [27], [29].
Our work focused on this neglected topic by using multi-neuron patch clamp technique to record synchronized activities between individual neurons participating in electrical networks of the rat prefrontal cortex (PFC) under calcium-free conditions.
Calcium imaging experiments showed that the ACh induced synchronized activities still existed in the TTX treated early postnatal retinas [44], in forms of synchronized elevation in intracellular calcium among neighboring cells.
2) Twenty four hours after an injection, the vitreous extracts from an injected eye completely blocked synchronized firing of a pair of neighboring RGCs of another early postnatal retina (P7), suggesting the intraocular concentration was sufficient to block synchronized activities throughout the treatment (Fig. S2F).
Normal DS circuitry has been observed in the nicotinic ACh receptor β2 subunit deficient mice in which retinal synchronous activities were diminished [13], arguing that synchronized activities are not important.
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In the present paper we study synchronized activity in a neural network model whose dynamics is driven by an external activation.
For example, a study of scalp EEG in healthy subjects found evidence for synchronized activity between hand and foot areas during finger movements, and concluded that synchronization was occurring between distinct neuronal networks (Pfurtscheller et al., 2000).
For example, epileptiform discharges are associated with bursts of neural ensembles with highly synchronized activity [14].
When large numbers of neurons show synchronized activity, the electric fields that they generate can be large enough to detect outside the skull, using electroencephalography (EEG) or magnetoencephalography (MEG).
For both increased synchronized activity could be found in the PCC (BA31) for pure tone tinnitus patients (see Fig 5; p<.05).
Furthermore, a comparison between narrow band noise and a normative database revealed increased synchronized activity in the PCC and the beta and in the parahippocampal area for gamma.
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