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As such, these synaptic relationships governing the discharge patterns of rostral ventral respiratory column expiratory neurons could account for a cough expiratory interval composed of two subphases.
The combination of single neuron labeling and image registration we describe here represents a useful intermediate: it allows the substructure of an information-processing center to be defined according to input and output channels and predicts their synaptic relationships.
In this issue of Cerebral Cortex, 3 related papers provide the most comprehensive analysis to date of the cellular and synaptic relationships of a standard cortical column in the somatosensory cortex of the Wistar rat.
If we are ever to understand how deviation from normal cellular and synaptic relationships in the cerebral cortex affects the highest brain functions, we have to know the details of the composition of normal columns devoted to different functions.
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As we have shown, escape potentials under imperfect voltage clamp have a dramatic effect on the contribution of NMDA-R currents to the synaptic IV relationships.
Confocal-, light- and subsequent electron microscopy was performed to investigate their developmental regulation, morphology, synaptic input output relationships and electrophysiological properties.
Neighboring inhibitory inputs will tend to reduce NMDA-R activation and linearize the synaptic IV relationship, to a point at which the NMDA-R mediated non-linear component becomes virtually undetectable.
Although the issue of the synaptic input output relationship of CR cells with local and distant networks is essential to understand their functions in the developing and mature hippocampus, several key points remain unresolved.
Our results show that the information on the network period and phase can be obtained using maps that keep track of observable network variables such as the intrinsic periods of the neurons involved, their phase response curves and the synaptic plasticity profiles: relationships describing how the synaptic strength depends on input frequency.
In both synaptic pathways, the relationships were roughly U-shaped.
In simple binomial models of synaptic transmission, this relationship is to be expected when the unitary IPSP amplitude is primarily determined by the neurotransmitter release probability (Pr, cf., Katz and Miledi 1972).
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