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These preparations, unlike other experimental models such as acute and cultured cortical slices, are relatively free of predefined constraints and allow neurons to establish several synaptic links, creating highly-connected networks which exhibit complex dynamics characterized by highly-synchronized bursts and random spiking (Figures 1B and 1C).
Other things being equal, cells with larger numbers of between-area synaptic links are more likely than others to have such links potentiated.
In fact, in virtue of their rich synaptic links to other areas, these multimodal, higher-association zones (Damasio, 1989) act as "cortical hubs", linking primary sensory areas to motor ones and thus supporting the formation of distributed perception action circuits through learning.
Notice that the radius ρ and density of the connectivity had to be chosen in conjunction, as they determine the average number of synaptic links of a single E-cell: if the density increases, radius must decrease for the total number of synapses to remain constant and vice versa.
The number of strongly connected components in the model networks did not depart from unity, thus the underlying graph was not fractured and every constituent interneuron could be reached via a finite number of synaptic links from every other interneuron, even after the rhythm stopped.
The hub status of these areas means that their neurons exhibit, on average, a higher number of between-area (cortico-cortical) synaptic links than cells in primary (or secondary) areas, and, hence, are more likely to take part in the formation of perception-action circuits.
Similar(52)
Neurexins present on the presynaptic membrane are thought to bind neuroligins on the postsynaptic membrane, thereby forming a trans-synaptic link that helps maintain the close apposition of pre- and post-synaptic elements [63].
Reif, R. et al. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation.
Anandamide levels in the basolateral amygdala were increased by extinction training and augmented by systemic AM3506, whereas application of AM3506 to amygdala slices promoted long-term depression of inhibitory transmission, a form of synaptic plasticity linked to extinction.
A recent study suggests that functional connections, at least to a certain extend, describe anatomical connectivity (the set of physical or structural (synaptic) connections linking neuronal units at a given time) because they follow the rules of spike timing dependent plasticity [18].
As trafficking of AMPA receptors underlies forms of synaptic plasticity linked to learning, this disruption may explain the learning deficits associated with AD.
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