In addition, the symptoms data are self-reported by the study participants.
With regard to the need to distinguish primary and secondary symptoms, data are conflicting regarding the benefit of clozapine.
We collect symptoms data from February 20 , 2013 and March 21 , 2013ince in thisinceind we have a high presence of flu-like and cold sympthis.
In particular, we focus only on collecting one month of symptoms data in order to have a high participation rate from our study participants.
Thus, given a date t, we consider valid a time window of five days if the following conditions are satisfied: (i) mobility data for (t_{mathrm{hist}} in [0,2]), and (ii) symptoms data for the time (t_{mathrm{hor}}in [0,2]).
No changes were observed in the control regions for individual symptoms (data not shown).
Similar differences in age were noted when we assessed age at onset of symptoms (data not shown).
In all chlorotic or necrotic systemic leaves tested, we never detected the presence of bacteria except for the rare leaves exhibiting maceration symptoms (data not shown).
Also, there were no differences in the socioeconomic and educational background, which may influence the promptness to consult by symptoms (data not shown).
It is worth noting that the fur mutant is unable to induce any disease symptoms (data not shown), as already reported in Xoo [39].
Otherwise, no significant differences in the number of patients reporting new-onset gastrointestinal symptoms were observed between treatments either as separate symptoms (data not shown) or as any new-onset gastrointestinal symptom (metformin: n = 43; placebo: n = 39; p = 0.310).
