Your English writing platform
Discover LudwigSuggestions(5)
Exact(6)
Therefore, allergen-specific basophil reactivity shows daily variations depending on the circadian clock activity in basophils, which could partly explain temporal symptomatic variations in allergic rhinitis.
To explore the cellular mechanism(s) behind the daily symptomatic variations in allergic rhinitis, we determined whether allergen-specific basophil reactivity exhibited a time-of-day-dependent variation in patients with seasonal allergic rhinitis (SAR).
By testing outside the pollen season, we were able to avoid the influence of allergen exposure on basophil reactivity; however, allergen exposure might be of much greater significance for diurnal symptomatic variations.
Symptoms in allergic rhinitis are often most severe during overnight or early in the morning ('morning attack'), which results in poor daytime quality of life 1, 2. However, it remains poorly understood how the prominent ˜24-h symptomatic variations occur in allergic rhinitis.
Given that BM basophils have functional clockwork and IgE-mediated activation of BM basophils shows temporal variations relying on Clock, we propose that allergen-specific basophil reactivity shows daily variations depending on the circadian clock activity in basophils, which may partly explain temporal symptomatic variations in allergic rhinitis.
Diurnal functional variations in vessels, glands, nerves, hormones such as cortisol, mast cells, and eosinophils might be of more importance for the temporal variations in allergic rhinitis symptoms 1, 2, and basophils might be more like a surrogate marker for the symptomatic variations.
Similar(54)
Interestingly, more robust predictors of treatment response were identified when the symptomatic variation in depression was explored in terms of dimensional traits (rather than the above categorical subtypes).
Oliveria and colleagues [ 56] illustrated this variation in symptomatic OA incidence by sex and joint over time.
Additionally, we may be able to learn something about the variation in the symptomatic or asymptomatic natures in the epidemics dynamics of certain diseases.
Assessment of change in OHS between preoperative and postoperative assessments revealed that patients achieved substantial and clinically relevant symptomatic improvement (change), regardless of variation in these patient and surgical factors.
The increased life expectancy and the tendency for obesity in younger individuals have lead to an increased prevalence of the symptomatic knee OA with broad variation among different populations[ 1].
More suggestions(2)
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com