Yet despite these essential efforts, we've yet to see the emergence of any major initiatives focused on confronting the root cause of these symptomatic problems: the very structure of our economic system itself.
The decision to initiate treatment is based upon 1) failure of standard therapy, 2) the presence of disease that threatens vital structures, 3) symptomatic disease, and/or 4) clinically significant disease with radiographic progression.
Normative data is important for evaluating cerebral structure size in symptomatic term infants and assessing preterm brain growth by term age.
When mild neuronal loss was observed in any gray matter structure, both in symptomatic gene carriers and controls, it was not interpreted as being significant for RDP.
Oral administration of diacerein to patients with hip OA was associated with symptomatic improvement and a significant structure modifying effect, coupled with a good safety profile [ 11].
To our knowledge, our study is the first to quantify the effect of symptomatic hypoglycemia on chronic brain structure changes in a large clinical cohort of treated older T2DM patients.
In general, MKIs should be reserved for patients with limited alternative options for symptomatic disease, disease threatening vital structures, or rapidly progressive disease.
Shoulder impingement syndrome is the most common clinical diagnosis for patients with shoulder pain [ 8, 9] and can be defined as a symptomatic compression of the subacromial structures during elevation of the arm [ 10, 11].
As demonstrated in Fig. 5, the fall in fractional anisotropy in the fornix and cingulum of the SMC group appeared to be driven by an increase in radial diffusivity; very little difference in axial diffusivity was seen in these structures between the symptomatic mutation carriers and control subjects.
