The purpose of distinguishing a calf compartment was two-fold: (a) to investigate the differential effects of varying local (calf) vs. global (body) parameters in the present study; and (b) in preparation for future modelling of and comparative investigations against PAD patients whose calf muscles are common symptomatic sites of tissue ischemia and impaired angiogenesis [43], [65]).
Prevotella intermedia also exists at the diseased site of periapical periodontitis [ 13, 16, 17] and shows a significantly higher detection ratio in symptomatic sites than in asymptomatic sites [ 13].
This characterization of MS based on the number of symptomatic sites regardless of the anatomical sites appears to be particularly suitable to study widespread pain according the American College of Rheumatology definition (WSP) [ 25, 26].
Patients who received focal radiation to symptomatic sites at the time of diagnosis of MM were included only if the radiation was administered at the time of initial diagnosis before initiation of systemic therapy.
If the asymptomatic and symptomatic sites overlap as in the case of respiratory disease, sneezing and coughing generated by the lung-adapted phenotype could favour transmission of freeriders that remain adapted to the nasopharynx, even when disease is a dead end (i.e. revertant changes do not occur, thus preventing transmission of revertant cells to the nasopharynx of new hosts).
In most studies, non-symptomatic sites were visualized in order to exclude pathologic findings prior to dental implant surgery [1, 7, 23, 24, 29, 30].
Recent studies support a more global approach to musculoskeletal disorders analysing the extent of musculoskeletal symptoms (MS) and especially the number of symptomatic anatomical sites rather than a particular site, either in the general population [ 5- 17] or in the working population [ 18- 24].
Symptomatic injection-site reactions can be managed with warm compresses and oral antihistaminics.
Some patients deserved magnetic resonance imaging or computerized tomography to assess the symptomatic bony sites with negative skeletal survey, suspected cord compression or size of tumor mass.
In Kahn's series, radiation therapy was received by 5806 of the 16 023 women, but no information was provided on whether it was directed to the breast, the chest wall, or osseous or symptomatic metastatic sites [ 13]; Rapiti and colleagues reported that women who had surgery (and especially breast-conserving surgery) were more likely to have local radiotherapy too (21% vs 5%; P < 0.0001) [ 16].
