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We focused on symptomatic medication overuse and concurrent prophylaxis therapy.
A 1-month headache diary was used to collect clinical data and symptomatic medication.
A considerable number of these patients eventually make excessive use of symptomatic medication.
The use of symptomatic medication may lead to the paradoxical development of medication-overuse headache.
Smoking, sex, symptomatic medication use are other factors that can affect the oxidative stress status.
In order to properly reflect a real-life setting, we did not exclude patients with symptomatic medication overuse.
Overuse of symptomatic medication for headaches may lead to drug resistance and even transformation into refractory medication overuse headache [3].
Excessive symptomatic medication may conduct to medication overuse (MO) which has been proposed as a risk factor for migraine transformation.
Finally, there is strong evidence that prophylactic and symptomatic medication have an impact on the reduction of emotional problems.
Patients were allowed to take frovatriptan as symptomatic medication, whose efficacy was evaluated at the two hours pain-free rate.
Most of these patients (50 80%) fulfilled criteria of symptomatic medication overuse with all its somatic and psychological implications [2].
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