The selection of symptomatic items was developed based on the opinions of the panelists and not assessed through an experimental investigation.
The YZ body constitution was assessed by a questionnaire, which was developed using a psychometrically sound method as reported previously [ 31], and comprises eight self-reported symptomatic items(Supp).
Its 20 symptomatic items are self-assessed to identify the number of days per week a subject is affected by depression, as "none", "1 to 2 days", "3 to 4 days", "5 or more days," providing for a total score of 0 to 60, with a higher score representing a stronger tendency toward depressive feelings.
Construction and validation of aggregate scores was by factor analysis for (1) beliefs about cancer outcomes, (2) beliefs about barriers to symptomatic presentation, and item summation for (3) awareness of cancer symptoms and (4) awareness of cancer risk factors.
'Barriers to symptomatic presentation' combined four items (too embarrassed, too busy, worried about wasting the doctor's time and worried about what the doctor might find).
When three or more people identified a specific symptomatic or functional impact, an item was included in theWURSS-44.
Here, the authors used a conservative definition of symptomatic remission with no symptom item on the ADHD-RS-IV endorsed as more severe than mild [ 28].
Statistical analyses refer to the number of missing values per item, percentage of symptomatic answers, age- or gender-related item bias, item total correlations, and resulting scale reliabilities Cronbach's Alpha.
The low ICCs found for some items may reflect symptomatic changes in the acute phase before and after chemotherapy.
In total, 22 symptomatic toxicities (41 PRO-CTCAE items), corresponding to the symptomatic adverse-events profile associated with the regimens commonly used for prostate cancer treatment (Docetaxel, Cabazitaxel, Abiraterone, Alpharadin), were selected.
