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Given the variability in the symptomatic experience of this patient population, the UC-PRO/SS is completed as a daily diary, and is designed for electronic administration.
Although a number of participants mentioned signs (fever) or diagnoses (dehydration, ear infection), these specific concepts were not considered candidates for the Flu-PRO symptom measure since they did not directly reflect patients' symptomatic experience, and symptoms of fever (warmth, chills, etc).
A study of adherence to ICS in community-managed asthma patients in the UK showed that for many patients, the medical model of asthma as a chronic condition requiring daily preventer treatment was perceived to be at odds with their symptomatic experience of asthma as an episodic condition (e.g. my asthma isn't there when I don't have symptoms).
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The inclusion criteria in the original RCT were: being symptomatic, experiencing daily hot flushes, age between 40 and 63 years, not using hormone therapy now or in the past 3 months, sedentary lifestyle and having last menstruated 3 36 months earlier.
Malterud and Baerheim [ 10] explored the symptomatic experiences of 94 Norwegian women with UTIs and reported an 'unexpected finding' of accompanying systemic symptoms including tiredness, inability to concentrate, and irritability.
Criteria for inclusion in the intervention study were: being symptomatic, experiencing daily hot flushes, age between 40 and 63 years, not using HRT now or in the past 3 months, having a sedentary lifestyle (with aerobic training under twice a week) and having last menstruated 3 36 months earlier.
The domains were designed to be scored based on the totality of the subjects' symptomatic disease experience.
Most symptomatic persons experience acute systemic febrile illness; West Nile neurologic disease develops in <1% of infected persons but has a case-fatality rate of 9% (2 ).
Despite a much wider range of medical and surgical treatment options, many young adults remain symptomatic and experience poor quality of life [ 11].
Symptomatic children experienced poor school performance.
This group further demonstrated the advantage of multiple biomarker modelling using data derived from symptomatic women experiencing preterm labour.
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