Exact(2)
Therefore, the failing myocardium is much more susceptible to negative inotropic effects because of a blunted contractile reserve subsequent to decreased sympathetic sensitivity or a negative force-frequency relation.
Moreover, patients with heart failure are much more susceptible to negative inotropic drugs because of blunted contractile reserve subsequent to decreased sympathetic sensitivity [ 1] or negative force frequency relationship [ 13].
Similar(58)
Vascular caliber may reflect adrenergic tone and sympathetic receptor sensitivity.
The SNP dose-dependent curves for sympathetic baroreflex sensitivity (ΔHR/ΔMABP versus SNP and ΔHRR versus ΔMABP were plotted but showed no differences between control, DM, and DM + DMC groups.
The sympathetic baroreflex sensitivity was not changed in control rats after administrated with DMC (data not shown, P > 0.05) Ctr: control group; DM: diabetic mellitus; DMC: Daming capsule; MABP: Mean arterial blood pressure; HR: heart rate; PE: phenylephrine; SNP: sodium nitroprusside.
27 29 30 Vascular calibre can directly reflect adrenergic tone and sympathetic receptor sensitivity, as demonstrated in experimental and animal models of vasospasm in SAH. 31 32 Studies with spinal cord stimulation as a treatment of patients with coronary vasospasm showed ameliorated coronary perfusion independent of MAP, as did studies using transcutaneous electrical nerve stimulation (TENS).
Training-induced hypotensive effect is determined by physiological adaptations in the heart and vascular system, such as increased sympathetic baroreflex sensitivity in the heart, that is usually impaired by the hypertensive status [ 20], increased capillary density [ 21], and increased endothelial nitric oxide synthase (eNOS) levels causing endothelium-dependent vasodilatation [ 22].
That aside, it is a convincing portrait, rendered with skill and sensitivity, sympathetic toward its subject while capturing the quirks that made him, in the words of one contemporary, "so Arthurish". Schlesinger is so closely identified with the Kennedys that it can be hard, today, to appreciate just how fully formed a public figure he was before Camelot.
Could increased sympathetic tone or sensitivity to norepinephrine be responsible for alterations in adipose morphology and the expression of critical gene products?
Mrs. Clinton said she was sympathetic to political sensitivities in Japan, but she left little doubt that American patience was wearing thin.
Recurrent nocturnal hypoxemia in obstructive sleep apnea enhances sympathetic function, decreases baroreceptor sensitivity, and weakens peripheral vascular responses to adrenergic signals.
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