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MAP3K9 (synonym MLK1) is a member of the MLK family of serine/threonine kinases and is known to activate the JNK pathway by phosphorylating (activating) MKK7 (symbol MAP2K7) upstream of JNK [ 29].
Upon binding to double-stranded RNA or double-stranded DNA, OAS proteins and cGAS produce nucleotide second messengers to activate RNase L and STING (stimulator of interferon genes, gene symbol: TMEM173), respectively; this leads to the initiation of antiviral responses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com