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However, the rate of AEs including diarrhea, food-hand reaction, and neuropathy was significantly higher in patients continuing chemotherapy than in patients switching to maintenance treatment [ 18].
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The drug was discontinued, and treatment was switched to maintenance risperidone 1 mg.
After 48 hours, cells were switched to maintenance DMEM medium containing 10% FBS and 830-nM insulin for the remaining duration of differentiation.
At 2 weeks after the first passage, the cells were switched to maintenance medium containing N2 supplement (1%; Invitrogen) and 20 ng/ml EGF.
Once disease control has been achieved, treatment can be switched to maintenance therapy with a better tolerated drug.
On remission and after 3 to 6 months of treatment, patients were switched to maintenance therapy with azathioprine and low-dose prednisolone.
After successful remission induction (of 3 to 6 months), MPA and WG patients should be switched to maintenance therapy with medium-potent immunosuppression (azathioprin, MTX or leflunomide) [ 47- 49].
However, these patients would have an improved outcome if they switched to maintenance treatment with less potent and toxic drugs [ 2].
If a patient receives ECT and reaches remission earlier than six weeks, the ECT treatment is terminated and the patient is switched to maintenance therapy.
If splenectomy, romiplostim, and rituximab are all ineffective or relapse occurs, then the patient is switched to maintenance therapy using corticosteroids.
A 25-OHD measurement should be repeated and if it is greater than or equal to 75 nmol/L (30 ng/mL), the patient can be switched to maintenance therapy with at least 1000 units/day of oral cholecalciferol.
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