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The switching role of thyroxine (T4) follows already from its prognostic evidence alone.
Notably, PERK signaling is cell fate deciding in ER stress because of its autophagy apoptosis switching role.
The process of withdrawing treatment involves switching role from that of an "advocate" for curative or disease modifying treatments to a supportive "counselling" role for palliative, end of life care [ 49].
For example, a switching role of serum iron may be explained from its known role as a protagonist of oxidative damage through catalytic generation of ROS (dominating its early effect) (Xu et al., 2010) and as a correlate of anaemia (dominating its late effect).
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Essentially, Hughes and Chamberlain are switching roles.
(The two will begin switching roles in late July and alternating in early August).
She is not about to give up her mission, but she's switching roles.
Some people are comfortable switching roles between sexual dominance and passivity, others are not.
The notion of Kate and Petruchio switching roles works beautifully, and speaks volumes.
Of nine actors, eight are double-cast, often switching roles from moment to moment.
Soon, the two of them are playing this game explicitly, switching roles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com