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Tadele, the leader today, is constantly changing course, switching pathways, often shunning the trails altogether to leap across rocks.
One limitation of this study is that it only focuses on two product switching pathways.
All these findings could in principle be reflecting differential contributions of the switching pathways at different developmental or immunological stages; in particular, the effects of SMUG1 deficiency are more apparent with age, as the relative inefficiency of the SMUG1 pathway is only able to compensate for UNG deficiency over time.
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PRR is a type of DNA repair mechanism that uses translesion synthesis (TLS) or the error-free template switching pathway to resolve the DNA lesions encountered by DNA polymerase (Bergink and Jentsch, 2009; Sale et al., 2012).
Understanding this specific switching pathway represents fruitful grounds for future research.
There is good evidence from several systems that one form of fork restart works through a template switching pathway, with recovery through a Holliday junction-like structure (Atkinson and McGlynn 2009; Lambert and Carr 2013).
In STEP-BD, patients could switch pathways based on doctor's or their own preference as well as inclusion and exclusion criteria.
Some of the individual axons that could be traced from injection site to growth cone or terminal arbor traveled exclusively in one substrate, others switched pathways, for example, from the infracortical fasciculus to the white matter, avoiding the subplate (Figure 4 C); or alternated travel between two substrates.
They concluded that pathway switching or pathway branching effect appears to be responsible for the sharp response to oxygen concentration.
Taken together, the results suggest that Ser phosphorylation is not an on/off trigger mechanism for switching metabolic pathways, but rather a fine-tuned mechanism for carbon allocation within different metabolic pathways.
It is, of course, possible that the nonseed, motif interactions have additional functions, e.g., in attracting regulatory factors or switching effector pathways.
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