Exact(7)
Therefore, writers that can also read the histone modifications are required for the establishment and maintenance of chromatin states at active and repressed genes and may play important roles in the memory and switching of gene expression states.
These negative feedback loops reinforce the maintenance of distinct chromatin states, and may play an important role for switching of gene expression during differentiation and development by creating and reinforcing a bistable state.
Phenotypic switching can be dictated by epigenetic switching of gene expression.
Here we sought to explore the genomewide relation of chromatin silencing and stochastic switching of gene expression in S. cerevisiae.
This finding might point towards a major post-meiotic switching of gene expression from the sporophytic to the gametophytic mode.
As we have seen in the case of H3K27 methylation and acetylation, negative crosstalk is also involved in the switching of gene expression states.
Similar(53)
It should be noted that here, as was the case in consideration of the role of DNA methylation, it is the switching off of gene expression that drives tumour progression.
Investigating the cellular distribution of miRNAs deregulated in psoriasis we found that these master switches of gene expression are expressed in cells with key roles in the pathogenesis of psoriasis.
Herein, we describe the method to select ribozyme-based switches of gene expression in Saccharomyces cerevisiae that we successfully implemented to engineer neomycin- and theophylline-responsive switches.
Gene expression profiling showed extensively decreased epithelial markers and increased mesenchymal markers in EPT1 cells, as well as pronounced switches of gene expression modules involved in cell adhesion and attachment.
Additionally, repeats located within regulatory regions might constitute an on/off switch of gene expression at the transcriptional level [ 50].
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