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These studies have shown that P. falciparum var gene activation within a clonal parasite population does not follow a predetermined order, but instead the transcriptional switching rate depends on the on/off rate of the genes and chromosomal location, with subtelomerically located genes exhibiting the highest switching rate, regardless of switching history [33], [31].
As both parasite clones studied herein expressed upsC var-genes at onset and both eventually converged to var2csa transcription, and given that the var switching history of a particular parasite has been shown to result in a particular switching rate [30], it is possible that switching to var2csa is favored in parasites previously transcribing a particular group of var-genes (upsC).
Similar(58)
At some point, the narrative switches to alternate history.
How do I enroll in History or switch into History from another concentration?
Genachowski was on the pre-med track before switching to history in 1982.
He lived in Livingston (now Wallach) Hall, entering as an engineering student but switching to history after higher level calculus and chemistry courses confounded him.
It is this which not only saves the day but switches history.
Psychoanalytic theory reached the peak of its impact in the late fifties, when Crews was switching from history-of-ideas criticism to psychoanalytic criticism, and it began to fade in the late sixties, when Crews was starting to notice a certain circularity in his graduate students' papers.
Young Mr. Garrett switched to history, receiving a bachelor's degree.
Returning to Oxford, Stewart switched from history to philosophy, politics, and economics (P.P.E).
After a year on the classics ladder, he opted for science, then switched to history.
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